Platelets/Lymphocytes Ratio (PLR)

A simple ratio from your blood count that hints at your body’s inflammation balance.

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Platelets/Lymphocytes Ratio (PLR)
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Test Summary

Sample Type 
Blood
Required Blood
1 mL
Analysis Type
Whole blood
Collection method
In person at the lab; at-home where available

Why test

Platelets/Lymphocytes Ratio (PLR)

?

Clinicians sometimes review PLR to get a quick sense of inflammatory balance using routine blood counts. It may add context when evaluating symptoms, recovery, or long-term risk, especially alongside other inflammation tests. PLR is research-supported but not guideline-endorsed; trends over time are more helpful than a single result. You can test this marker with Aniva across Germany and Finland.

What is

Platelets/Lymphocytes Ratio (PLR)

?

Clinicians sometimes review PLR to get a quick sense of inflammatory balance using routine blood counts. It may add context when evaluating symptoms, recovery, or long-term risk, especially alongside other inflammation tests. PLR is research-supported but not guideline-endorsed; trends over time are more helpful than a single result. You can test this marker with Aniva across Germany and Finland.

What insights will i get from

Platelets/Lymphocytes Ratio (PLR)

?

High: May reflect increased inflammatory activity or physiologic stress, sometimes after infection, smoking, strenuous exercise, or surgery. Review platelet and lymphocyte counts and consider pairing with CRP for context.
Low: May occur with lower platelets or relatively higher lymphocytes, such as during recovery from illness or after certain medicines. Look at trends and other CBC markers for a clearer picture. PLR is not guideline-endorsed; no standardized cutoffs.

Sample type & collection

  • Sample: Blood (EDTA, whole blood)
  • Fasting: No
  • Best timing: Morning, when well-rested and hydrated
  • Collection: Venous blood draw; EDTA (purple-top) tube
  • Typical volume: 1 mL
  • Analysis: Automated CBC; calculated as platelets ÷ lymphocytes
  • Prep tips: Avoid heavy exercise, alcohol, and smoking for 24 hours; drink water
  • Turnaround: 1–3 business days

Track your

Platelets/Lymphocytes Ratio (PLR)

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Platelets/Lymphocytes Ratio (PLR)
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Limits & interferences with

Platelets/Lymphocytes Ratio (PLR)

:

Common factors that can shift PLR include dehydration, recent vigorous exercise, alcohol, smoking, psychological stress, and poor sleep. Medications such as corticosteroids, beta-agonists, NSAIDs, antiplatelet drugs, and chemotherapy can alter platelet or lymphocyte levels. Omega-3 and some herbal supplements may affect platelets. Recent vaccination, menstrual phase, pregnancy, and delays in sample processing can also influence results.

Special situations (when to confirm or adjust): repeat if you were acutely ill, just had surgery, are pregnant, or recently changed medicines.

Questions about

Platelets/Lymphocytes Ratio (PLR)

:

What does a high or low PLR mean? High PLR can signal more inflammatory activity or stress. Low PLR may reflect lower platelets or relatively higher lymphocytes. Always interpret with other CBC results.

Do I need to fast for this test? No. Fasting is not required. Staying hydrated and avoiding heavy exercise beforehand can help.

What can affect my PLR result? Smoking, alcohol, strenuous exercise, stress, dehydration, recent vaccination, and medicines like steroids or NSAIDs can shift the ratio.

How often should I check PLR? There’s no set schedule. It’s usually rechecked when monitoring recovery, symptoms, or trends alongside a CBC.

How long do results take? Most labs report within 1–3 business days, depending on workload and transport.

What should I discuss with my clinician? Ask how PLR fits with your CBC, CRP, symptoms, and medications. Discuss whether repeat testing is useful.

Sources:

  • MedlinePlus — Complete Blood Count (CBC). (2024). https://medlineplus.gov/lab-tests/complete-blood-count-cbc/
  • ARUP Consult — Complete Blood Count with Differential. (2023). https://arupconsult.com/content/complete-blood-count-cbc
  • NHS — Full blood count (FBC). (2023). https://www.nhs.uk/conditions/diagnostic-tests/full-blood-count-fbc/
  • Mayo Clinic — Complete blood count (CBC). (2023). https://www.mayoclinic.org/tests-procedures/complete-blood-count/about/pac-20384919
  • NIH NLM — Platelets in inflammation and immunity. (2015). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475881/
Medical disclaimer: This content is for informational purposes only and is not medical advice. Always discuss results with a qualified healthcare professional.

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