Red Blood Cell Distribution Width Index (RDWI)

A calculated index from CBC results that helps sort common causes of small red cells.

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Test Summary

Sample Type 
Blood
Required Blood
1 mL
Analysis Type
Whole blood (EDTA)
Collection method
In person at the lab; at-home where available

Why test

Red Blood Cell Distribution Width Index (RDWI)

?

Clinicians use RDWI to help tell iron deficiency from inherited traits when red cells are small. It can guide next steps like iron studies or hemoglobin testing, especially when CBC results are mixed. RDWI is a supportive tool and should be interpreted with your full blood picture. You can test this marker with Aniva across Germany and Finland.

What is

Red Blood Cell Distribution Width Index (RDWI)

?

Clinicians use RDWI to help tell iron deficiency from inherited traits when red cells are small. It can guide next steps like iron studies or hemoglobin testing, especially when CBC results are mixed. RDWI is a supportive tool and should be interpreted with your full blood picture. You can test this marker with Aniva across Germany and Finland.

What insights will i get from

Red Blood Cell Distribution Width Index (RDWI)

?

High: Often points toward an iron-deficiency pattern, especially with a low MCV; confirm with iron studies.
Low: Can suggest a thalassemia trait pattern if MCV is low and RBC count is relatively high; confirm with hemoglobin analysis. Use RDWI alongside CBC, ferritin, and your history. Nutrition, bleeding, pregnancy, or recent transfusion can change patterns.

Sample type & collection

  • Sample: Blood
  • Fasting: No
  • Best timing: Morning is fine; avoid testing during acute illness
  • Collection: Venipuncture into EDTA (purple-top) tube
  • Typical volume: 1 mL
  • Analysis: Automated CBC (RBC, MCV, RDW); calculated RDWI
  • Prep tips: Stay hydrated; tell the lab about supplements or recent transfusion
  • Turnaround: 1–2 business days

Red Blood Cell Distribution Width Index (RDWI)

is best interpreted with:

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Red Blood Cell Distribution Width Index (RDWI)

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Red Blood Cell Distribution Width Index (RDWI)
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Limits & interferences with

Red Blood Cell Distribution Width Index (RDWI)

:

Common factors that may skew RDWI include recent blood loss or transfusion, iron/B12/folate supplements, pregnancy, inflammation or infection, dehydration, strenuous exercise, high altitude, smoking or alcohol use, and delayed or poorly mixed EDTA samples. Always share recent treatments and symptoms with your clinician.

Special situations: After transfusion, during pregnancy, or with acute illness, confirm results with repeat testing or additional studies.

Questions about

Red Blood Cell Distribution Width Index (RDWI)

:

What does a high or low RDWI mean? Higher values can fit an iron-deficiency pattern. Lower values may fit a thalassemia trait pattern. Always confirm with follow-up tests.

Do I need to fast for this test? No. RDWI uses CBC values, and fasting is not required.

What can affect my RDWI results? Recent transfusion, iron or vitamin therapy, pregnancy, inflammation, dehydration, altitude, and hard workouts can shift CBC values.

How often should I check RDWI? Usually only when anemia is suspected, being treated, or rechecked. Your clinician will guide timing.

How quickly are results ready? Most CBC-based calculations are available within 1–2 business days.

What should I discuss with my clinician? Share symptoms, diet, bleeding history, medications, and any transfusions. Ask whether to order iron studies or hemoglobin analysis.

Sources:

  • MedlinePlus — RDW (Red cell distribution width) test. (2024). https://medlineplus.gov/lab-tests/rdw-red-cell-distribution-width/
  • American Academy of Family Physicians — Evaluation of Microcytosis. (2010). https://www.aafp.org/pubs/afp/issues/2010/1101/p1117.html
  • ARUP Consult — Thalassemias. (2023). https://arupconsult.com/content/thalassemias
  • British Society for Haematology — Guidelines for the management of iron deficiency anaemia in adults. (2021). https://b-s-h.org.uk/guidelines/guidelines/iron-deficiency-anaemia-in-adults
  • Mayo Clinic — Complete blood count (CBC). (2023). https://www.mayoclinic.org/tests-procedures/complete-blood-count/about/pac-20384919
Medical disclaimer: This content is for informational purposes only and is not medical advice. Always discuss results with a qualified healthcare professional.

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