DHEA-Sulfate

DHEA‑Sulfate is an adrenal hormone that helps assess androgen balance and adrenal health.

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Test Summary

Sample Type 
Blood
Required Blood
1 mL
Analysis Type
Serum
Collection method
In person at the lab; at-home where available

Why test

DHEA-Sulfate

?

Clinicians order DHEA‑S when there are signs of androgen imbalance, such as excess hair, acne, or irregular periods, or when early puberty is suspected. It helps show whether extra androgens are coming from the adrenal glands and can guide follow‑up testing. It may also support evaluation of fertility concerns and possible adrenal disorders. You can test this marker with Aniva across Germany and Finland.

What is

DHEA-Sulfate

?

Clinicians order DHEA‑S when there are signs of androgen imbalance, such as excess hair, acne, or irregular periods, or when early puberty is suspected. It helps show whether extra androgens are coming from the adrenal glands and can guide follow‑up testing. It may also support evaluation of fertility concerns and possible adrenal disorders. You can test this marker with Aniva across Germany and Finland.

What insights will i get from

DHEA-Sulfate

?

High: May suggest extra adrenal androgen production. This can appear with conditions like polycystic ovary syndrome or other adrenal causes. DHEA supplements can raise results.
Low: May reflect reduced adrenal activity, pituitary issues, or steroid medicines. Levels naturally decline with age. If results are unexpected, consider repeating the test and reviewing medicines and supplements with your clinician. Reference ranges vary by age and sex.

Sample type & collection

  • Sample: Blood
  • Fasting: No
  • Best timing: Morning preferred for consistency
  • Collection: Standard venipuncture into serum tube
  • Typical volume: 1 mL
  • Analysis: Serum
  • Prep tips: Avoid DHEA supplements and high‑dose biotin 24–48 hours before, if safe
  • Turnaround: 1–3 business days

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DHEA-Sulfate

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Limits & interferences with

DHEA-Sulfate

:

Common factors that can skew results include DHEA supplements, oral contraceptives, glucocorticoids, some anti‑seizure drugs, biotin, pregnancy, age, acute illness, and intense exercise. DHEA‑S varies little by time of day, but a morning draw improves consistency.

Special situations: in children, pregnancy, menopause, or steroid therapy, use age‑ and sex‑specific ranges and consider repeat or confirmatory testing.

Questions about

DHEA-Sulfate

:

What do my DHEA‑S results mean? Higher values suggest extra adrenal androgen activity; lower values may reflect reduced adrenal output or certain medicines. Age and sex affect ranges.

Do I need to fast for this test? No. Fasting is not required for DHEA‑S testing.

What can affect my result? DHEA supplements, steroid medicines, birth control pills, high‑dose biotin, illness, and intense exercise may change or skew results.

How often should I test DHEA‑S? Most people test only when symptoms or treatment plans call for it. Your clinician may repeat it to confirm changes.

How long do results take? Many labs report results within 1–3 business days.

What should I discuss with my clinician? Share symptoms, cycle details, and all medicines or supplements. Ask whether related hormone tests are recommended.

Sources:

  • MedlinePlus — DHEA Sulfate (DHEAS) Test. (2023). https://medlineplus.gov/lab-tests/dhea-sulfate-dheas-test/
  • Endocrine Society — Hirsutism: Evaluation and Treatment. (2018). https://www.endocrine.org/clinical-practice-guidelines/hirsutism
  • ARUP Consult — Hirsutism and Virilization. (2023). https://arupconsult.com/content/hirsutism-and-virilization
  • Mayo Clinic Laboratories — Dehydroepiandrosterone Sulfate, Serum. (2024). https://www.mayocliniclabs.com/test-catalog/Clinical+and+Interpretive/8591
  • NIDDK — Polycystic Ovary Syndrome. (2020). https://www.niddk.nih.gov/health-information/endocrine-diseases/polycystic-ovary-syndrome
Medical disclaimer: This content is for informational purposes only and is not medical advice. Always discuss results with a qualified healthcare professional.

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