Systemic Immune-Inflammation Index

A combined score from your blood count that reflects your body’s overall inflammation and immune balance.

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Systemic Immune-Inflammation Index
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Test Summary

Sample Type 
Blood
Required Blood
Analysis Type
Whole blood
Collection method
In person at the lab; at-home where available

Why test

Systemic Immune-Inflammation Index

?

Clinicians may use SII to get a broader view of inflammation and immune stress, especially alongside CRP and a complete blood count. It can help track recovery from illness, monitor patterns in chronic conditions, or provide context during treatment follow-up. People with frequent infections, chronic inflammation, or ongoing therapies may benefit from watching trends rather than single values. You can test this marker with Aniva across Germany and Finland.

What is

Systemic Immune-Inflammation Index

?

Clinicians may use SII to get a broader view of inflammation and immune stress, especially alongside CRP and a complete blood count. It can help track recovery from illness, monitor patterns in chronic conditions, or provide context during treatment follow-up. People with frequent infections, chronic inflammation, or ongoing therapies may benefit from watching trends rather than single values. You can test this marker with Aniva across Germany and Finland.

What insights will i get from

Systemic Immune-Inflammation Index

?

High: May suggest higher inflammatory activity or physiological stress, often seen during infections or flares. Consider rechecking when you’re well and review with CRP and your CBC differential.
Low: May reflect a lower inflammatory burden or a more lymphocyte-leaning balance. Low values can also occur if platelets or neutrophils are reduced; context matters. Focus on trends over time and discuss next steps with your clinician.

Sample type & collection

  • Sample: Blood
  • Fasting: No
  • Best timing: Morning; repeat at the same time for trends
  • Collection: Venipuncture into EDTA tube
  • Typical volume:
  • Analysis: Automated CBC with differential; SII is calculated
  • Prep tips: Avoid strenuous exercise, alcohol, and dehydration for 24 hours, if possible
  • Turnaround: 1–3 business days

Track your

Systemic Immune-Inflammation Index

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Systemic Immune-Inflammation Index
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Limits & interferences with

Systemic Immune-Inflammation Index

:

Common factors that can skew results include current infection or fever, recent vaccination, surgery or injury, heavy exercise, dehydration, smoking, and alcohol. Medicines such as corticosteroids, chemotherapy, growth factors, and immunosuppressants can change white cells and platelets. Pregnancy, stress, time of day, and delayed sample processing may also shift counts.

Special situations: if you are pregnant, have a blood disorder, or receive chemotherapy, growth factors, or steroids, confirm timing and interpretation with your clinician.

Questions about

Systemic Immune-Inflammation Index

:

What does a high or low SII mean? High values may point to more inflammation or immune stress. Low values may reflect a lower inflammatory burden. Your symptoms and other labs provide context.

Do I need to fast for this test? No. Fasting is not required for SII or a standard complete blood count.

What can affect my result? Recent illness, vaccines, hard workouts, dehydration, pregnancy, smoking, alcohol, and medicines like steroids or chemotherapy can shift counts.

How often should I test? Timing depends on your care plan. Many people recheck during treatment follow-ups or after symptoms change.

How long do results take? Most labs report within 1–3 business days, often sooner for routine CBC-based measures.

What should I discuss with my clinician? Review trends, recent illnesses, and all medications or supplements. Ask how SII fits with CRP and your complete blood count.

Sources:

  • MedlinePlus — Complete Blood Count (CBC). (2024). https://medlineplus.gov/lab-tests/complete-blood-count-cbc/
  • ARUP Consult — Complete Blood Count (CBC) with Differential. (2023). https://arupconsult.com/content/complete-blood-count-cbc-with-differential
  • Mayo Clinic — Complete blood count (CBC). (2023). https://www.mayoclinic.org/tests-procedures/complete-blood-count/about/pac-20384919
  • Frontiers in Oncology — Systemic immune-inflammation index as a prognostic biomarker in cancer: A systematic review and meta-analysis. (2018). https://www.frontiersin.org/articles/10.3389/fonc.2018.00622/full
Medical disclaimer: This content is for informational purposes only and is not medical advice. Always discuss results with a qualified healthcare professional.

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