Monocyte / HDL Cholesterol Ratio (MHR)

A simple ratio balancing monocytes and “good” cholesterol to hint at inflammation and heart health.

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Test Summary

Sample Type 
Blood
Required Blood
Analysis Type
Serum and whole blood
Collection method
In person at the lab; at-home where available

Why test

Monocyte / HDL Cholesterol Ratio (MHR)

?

Clinicians may use MHR as an additional context marker for vascular inflammation and cardiometabolic risk. It can add nuance alongside standard tests if you have high cholesterol, diabetes, metabolic syndrome, or a family history of heart disease. Results can guide lifestyle focus and whether to follow up with routine lipids or inflammation testing. You can test this marker with Aniva across Germany and Finland.

What is

Monocyte / HDL Cholesterol Ratio (MHR)

?

Clinicians may use MHR as an additional context marker for vascular inflammation and cardiometabolic risk. It can add nuance alongside standard tests if you have high cholesterol, diabetes, metabolic syndrome, or a family history of heart disease. Results can guide lifestyle focus and whether to follow up with routine lipids or inflammation testing. You can test this marker with Aniva across Germany and Finland.

What insights will i get from

Monocyte / HDL Cholesterol Ratio (MHR)

?

High: May reflect higher inflammatory activity and/or lower HDL, signaling a less favorable cardiometabolic profile. Consider retesting when well, focus on heart-healthy habits, and review standard lipids and hs‑CRP with your clinician.
Low: May suggest lower inflammatory burden or more favorable HDL levels. Interpret within your overall risk factors and standard risk scores. Trends over time are more helpful than a single value.

Sample type & collection

  • Sample: Blood
  • Fasting: No
  • Best timing: Morning, when well; avoid testing during acute illness
  • Collection: Venipuncture into serum and EDTA tubes
  • Typical volume:
  • Analysis: Derived ratio from monocyte count (CBC) and HDL cholesterol
  • Prep tips: Hydrate; avoid heavy exercise and alcohol 24 hours before
  • Turnaround: 1–3 business days

Monocyte / HDL Cholesterol Ratio (MHR)

is best interpreted with:

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Monocyte / HDL Cholesterol Ratio (MHR)

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Monocyte / HDL Cholesterol Ratio (MHR)
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Limits & interferences with

Monocyte / HDL Cholesterol Ratio (MHR)

:

Common factors that can skew MHR include acute infections or inflammation, recent surgery or injury, strenuous exercise, smoking, and heavy alcohol use. Medicines that affect white blood cells (steroids, immunosuppressants) or lipids (statins, fibrates, niacin, estrogen therapy) can shift results. Non‑fasting is acceptable for HDL, but very large meals and dehydration may still nudge values. Try to test when you feel well and keep conditions similar between tests.

Special situations (when to confirm or adjust): pregnancy or postpartum, active autoimmune flares, cancer therapy, or within two weeks of vaccination or acute illness.

Questions about

Monocyte / HDL Cholesterol Ratio (MHR)

:

What does my MHR result mean? A higher MHR can suggest more inflammation and/or lower HDL. A lower MHR may indicate less inflammation. Use it with standard risk tests.

Do I need to fast for this test? No. Modern guidelines allow non‑fasting HDL. Keeping similar testing conditions helps compare results.

What can affect the result? Recent illness, hard workouts, smoking, alcohol, steroids, immunosuppressants, statins, fibrates, niacin, and hormone therapy can change MHR.

How often should I test it? Many people check it with routine blood work, often every 6–12 months, or when monitoring lifestyle changes.

How quickly will I get results? Most labs report the underlying CBC and HDL within 1–3 business days.

What should I discuss with my clinician? Review your MHR alongside a lipid panel, hs‑CRP, and overall risk. Ask whether any medicines or recent illnesses might have influenced the value.

Sources:

  • MedlinePlus — HDL Cholesterol Test. (2023). https://medlineplus.gov/lab-tests/hdl-cholesterol-test/
  • MedlinePlus — Complete Blood Count (CBC). (2022). https://medlineplus.gov/lab-tests/complete-blood-count-cbc/
  • ARUP Consult — Complete Blood Count with Differential. (2023). https://arupconsult.com/content/complete-blood-count
  • European Society of Cardiology — ESC/EAS Guidelines for the management of dyslipidaemias. (2019). https://www.escardio.org/Guidelines/Clinical-Practice-Guidelines/Dyslipidaemias
  • American Heart Association — Understanding Cholesterol Tests. (2024). https://www.heart.org/en/health-topics/cholesterol/understanding-cholesterol-tests
Medical disclaimer: This content is for informational purposes only and is not medical advice. Always discuss results with a qualified healthcare professional.

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