HOMA-Beta

An estimate of how well your pancreas makes insulin using fasting glucose and insulin.

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Test Summary

Sample Type 
Blood
Required Blood
Analysis Type
Serum
Collection method
In person at the lab; at-home where available

Why test

HOMA-Beta

?

HOMA-Beta helps show how active your insulin-making cells are. Clinicians use it with glucose, insulin, or HbA1c to understand insulin resistance and secretion. It can guide lifestyle focus and follow-up tests in prediabetes and type 2 diabetes. You can test this marker with Aniva across Germany and Finland.

What is

HOMA-Beta

?

HOMA-Beta helps show how active your insulin-making cells are. Clinicians use it with glucose, insulin, or HbA1c to understand insulin resistance and secretion. It can guide lifestyle focus and follow-up tests in prediabetes and type 2 diabetes. You can test this marker with Aniva across Germany and Finland.

What insights will i get from

HOMA-Beta

?

High: May mean your pancreas is making more insulin to compensate for insulin resistance or after certain therapies.
Low: May mean reduced beta-cell reserve, a pattern seen as type 2 diabetes progresses. Trends over time and testing under similar conditions give the best signal. Pair with HbA1c, fasting glucose, insulin, or C-peptide for clearer context.

Sample type & collection

  • Sample: Blood
  • Fasting: No
  • Best timing: Morning, ideally after 8–12 hours without food
  • Collection: In person at the lab; at-home where available
  • Typical volume:
  • Analysis: Serum
  • Prep tips: Avoid heavy exercise and alcohol the day before; keep routine meds unless advised
  • Turnaround: 1–3 business days

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HOMA-Beta

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HOMA-Beta
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Limits & interferences with

HOMA-Beta

:

Common factors that can skew results include not fasting, recent illness, intense exercise, alcohol, dehydration, and some medicines (steroids, beta-agonists, niacin). High-dose biotin supplements may interfere with certain insulin immunoassays. Pregnancy, acute stress, and big changes in sleep or diet can also shift glucose and insulin. Aim to test at a similar time of day with consistent prep.

Special situations: Insulin or secretagogue therapies (e.g., sulfonylureas), GLP-1 agonists, and pregnancy can alter results; discuss confirming or timing your test with your clinician.

Questions about

HOMA-Beta

:

What does a HOMA-Beta result mean in simple terms? It estimates how strongly your pancreas is making insulin at rest. Higher means more output; lower means less.

Do I need to fast for this test? Fasting is recommended because the calculation uses fasting glucose and insulin, but follow your lab’s instructions.

What can affect my result? Recent illness, heavy exercise, alcohol, biotin supplements, and some medicines can change glucose or insulin levels.

How often should I check HOMA-Beta? Many people repeat it every 3–6 months when monitoring metabolic health or after a treatment change.

How long do results take? Most labs report within 1–3 business days, depending on the insulin assay and processing.

What should I discuss with my clinician? Review trends, your glucose, insulin, HbA1c, medications, and whether another test like OGTT or C-peptide would add clarity.

Sources:

  • American Diabetes Association — Standards of Care in Diabetes. (2025). https://diabetesjournals.org/care/pages/standards-of-care
  • Diabetes Trials Unit, University of Oxford — HOMA2 Calculator. (2024). https://www.dtu.ox.ac.uk/homacalculator/
  • MedlinePlus — Insulin in blood test. (2024). https://medlineplus.gov/lab-tests/insulin-in-blood/
  • NIDDK — Prediabetes and Insulin Resistance. (2024). https://www.niddk.nih.gov/health-information/diabetes/overview/what-is-diabetes/prediabetes-insulin-resistance
  • U.S. FDA — Biotin interference with lab tests: Safety communication. (2019). https://www.fda.gov/medical-devices/safety-communications/biotin-interference-lab-tests-fda-safety-communication
Medical disclaimer: This content is for informational purposes only and is not medical advice. Always discuss results with a qualified healthcare professional.

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